Unvaccinated residents and staff were 3 to 4 times as likely to be infected compared to those who were vaccinated. In a single-centre study of an outbreak in a Kentucky (US) nursing home, 26 of 83 (31%) residents and 20 of 116 (17%) staff tested positive for SARS-CoV-2 after >90% of residents and >50% of staff had been vaccinated.After vaccinations started, 97 cases were detected, mostly during the start of the investigation period. In a small study of two Connecticut (US) nursing homes (463 residents overall) from December 2020 – February 2021, administration of the first dose of the vaccine was found to have 63% effectiveness against infection.This summary covers three studies of care homes that experienced outbreaks following Pfizer/ BioNTech vaccination demonstrate the vulnerability of care home populations in the period until vaccines develop their full protective effect and make the case for prioritising the completion of both doses. Evidence summary by Sian Smith, Maximilian Salcher-Konrad, Adelina Comas-Herrera ( Care Policy and Evaluation Centre, London School of Economics and Political Science)
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