![]() TUNEL showed that XFC could reduce cardiomyocyte apoptosis. ![]() Echocardiography showed that XFC could improve cardiac function. HE staining showed that XFC could improve the morphology of myocardial tissue. KEGG results showed that key genes were mainly enriched in lipid and atherosclerosis, PI3K-Akt signaling pathway, MAPK signaling pathway, and NF-κB signaling pathway. TNF, IL6, TP53, VEGFA, JUN, CASP3, and SIRT1 were the main targets of XFC. Network pharmacology showed that quercetin, kaempferol, β-sitosterol, luteolin, and baicalein were the main active ingredients of XFC. HE staining, echocardiography, immunofluorescence, and TUNEL were performed to verify the prediction results. Molecular docking was performed by Autodock Vina. KEGG and GO analyses were performed by Metascape Database. PPI analysis was performed by the STRING database. TCMSP, GeneCards, and DisGeNET databases were used to find the target of XFC. To explore the mechanism of anti-MI effects of XFC by combining network pharmacology and experiments. At present, the molecular mechanism of XFC remains unclear. Xuefu Zhuyu Capsule (XFC), a proprietary Chinese medicine, is widely used in various cardiovascular diseases. Myocardial infarction (MI) is the most severe manifestation of cardiovascular disease.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |